"Activatable" Nanomedicine Precise Chemotherapy Does Not Injury

With conventional cancer chemotherapy, normal tissue cells are also “falsely injured” and aggravate the patient’s pain. The reporter recently learned from Nankai University that the team of Guo Dongsheng of the school's chemistry school and the Dingdan team of the Life Sciences Academy have jointly researched and developed a “activatable” nanopharmaceutical for cancer chemotherapy that overcomes the lack of tumor targets in traditional photosensitizers. Due to the defects of tropism and phototoxicity to normal tissues, it has successfully achieved selective imaging and targeted therapy of animal tumors. Relevant achievements were also published in the new issue of the top issue of the Journal of the American Chemical Society.

According to reports, photodynamic therapy is becoming one of the important means of cancer treatment with its advantages of less trauma and simple operation. Photodynamic therapy requires the input of photosensitizers into the human body. Traditional photosensitizers have phototoxic effects on normal human tissues, which limits their use in clinical applications. How to improve the existing commercial photosensitizers has become a worldwide problem in recent years. The "activatable" photosensitizers for tumor treatment have also attracted the attention of the medical community.

Based on the study of calixarene supramolecular diagnosis and treatment, the group of Guo Dongsheng of Nankai University’s School of Chemistry creatively proposed a new strategy of “biomarker replacement and activation”. Starting from mature commercial photosensitizers, amphiphilic calixarenes are used. The photosensitizer binding method, through the interaction between the host and the guest, constructs a novel nanomedicine carrier with amphiphilic arene. After the chemical theory was verified, the Ding Dan Group of School of Life Science at Nankai University took the task of applying the strategy to imaging and treatment of living tumors. The research group injected nanomedicine into the tumor-bearing nude mice by tail vein administration. When the photosensitizer is contained in the main body cavity, its fluorescence imaging capability and photoactivity are almost completely quenched; when the nanomedicine is delivered to In the tumor tissue area, photosensitizers are displaced out of the cavity and reactivate their original photophysical properties, enabling selective imaging and targeted therapy of tumors.

(Reporter Sun Yusong correspondent Ma Chao)


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