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1. Intramuscular injection must be dissolved with sterile water for injection and be formulated as a solution containing 500,000 units per milliliter. Sodium chloride injection should not be used as a solvent. Severe cases can be diluted with sodium chloride injection to an intravenous infusion of 10,000 units per milliliter, while 5% glucose injection is prohibited, otherwise it will reduce efficacy.
2. The penicillin solution must be injected separately. Can not be mixed with vitamin B family, vitamin C, gentamicin, lincomycin, tetracycline, sulfadiazine sodium, dipyrone and other any other drugs mixed injection. Because penicillin is afraid of acid and alkali, but also afraid of oxidants, reducing agents, heavy metals, etc. (rubber tube or stopper made from zinc compounds can affect the penicillin activity), some produce muddy mixture, precipitation, some will make The efficacy of penicillin decreases or even fails.
3. The penicillin injection should be used now. If it is left for a long time, the efficacy will be reduced.
4. Penicillin sodium is a time-dependent antibiotic. In acute cases, it should be injected 3 to 4 times a day. Under normal circumstances, at least twice a day, the practice of increasing the dose only once a day is wrong.
5. Penicillin antibiotics are a fast-acting fungicide during the breeding period, and should not be used in combination with florfenicol, tetracyclines, macrolides, sulfa drugs and other antibacterial agents, especially for the treatment of meningitis or rapid sterilization. When severe infection occurs, antagonism will occur and interfere with the bactericidal activity of penicillin.
6. It is worthy to remind that many people currently lack an in-depth understanding of penicillin and analgin injections. In the treatment of certain "high fevers", it is a common practice to use analgin injection as a solvent. After penicillin was diluted, it was wrong. Because metamizole is a compound of aminopyrine and sodium sulfite, disodium acid disodium, the concentration of Analgin injection is 30%, very strong, itself is not easy to absorb, use it to dilute penicillin, is bound to also It affects the absorption of penicillin. It has been reported that dilute penicillin with Analzine can reduce penicillin by 30%. The 2005 edition of the Chinese Pharmacopoeia “Guidance Notes for Clinical Use†long ago stated that Analgin should not be mixed with other drugs.
How to use penicillin correctly
Penicillin antibiotics (including penicillin sodium, ampicillin, amoxicillin, etc.) are among the most widely used antibiotics in veterinary medicine. Mainly used for the treatment of Streptococcus, Staphylococcus and other gram-positive bacteria and certain gram-negative bacilli such as Pasteurella multocida and other infections, such as swine streptococcus, porcine, tetanus , Pneumoconiosis, actinomycosis, pyelonephritis, mastitis, metritis, pneumonia, sepsis, abscess, piglet exudative dermatitis and so on. There are many mistakes in the use of penicillin. The correct usage is as follows: