99% High Purity Sorafenib Tosylate for Anticancer Drug CAS 475207-59-1

Model NO.: 475207-59-1
Quality Standard: Bp, USP, Ep, Cp
Usage: Treating Cancer
Appearence: off-White Solid
Payment Method: T/T, Western Union, Money Gram, Paypal
Delivery Time: Shipped in 3 Days After Payment
Mf: C21h16clf3n4o3.C7h8so3
Shipping Method: EMS, DHL, FedEx, etc(Door-to-Door)
Trademark: Shinrezing
Transport Package: Foil Bag, Drum or Carton (Discreet Package)
Origin: Hubei
Model NO.: 475207-59-1
Quality Standard: Bp, USP, Ep, Cp
Usage: Treating Cancer
Appearence: off-White Solid
Payment Method: T/T, Western Union, Money Gram, Paypal
Delivery Time: Shipped in 3 Days After Payment
Mf: C21h16clf3n4o3.C7h8so3
Shipping Method: EMS, DHL, FedEx, etc(Door-to-Door)
Trademark: Shinrezing
Transport Package: Foil Bag, Drum or Carton (Discreet Package)
Origin: Hubei

Product Description

 

Product Name:Sorafenib tosylate
Other Name:Sorafinib mesylate;1-(4-Chloro-3-(trifluoroMethyl)phenyl)-3-(4-((2- (MethylcarbaMoyl)pyridin-4-yl)oxy)phenyl)urea Mono(4- Methylbenzenesulfonate);4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate
CAS:475207-59-1
MF:C21H16ClF3N4O3.C7H8SO3
MW:637.03
Assay:99%min
Appearence:White crystalline powder
Drug category:Anticancer drug
Purpose:This product is mainly used for the treatment of liver and renal cell carcinoma of the clinical anti-cancer agents.
Package:1kg/bag

Function&Usage
Sorafenib tosylate, also named nexavar, is a small-molecule anticancer compound. It is also a novel oral Raf kinase and a vascular endothelial receptor (VEGFR) inhibitor. It inhibits tumor cell proliferation and tumor angiogenesis [2]. To HepG2 cells (1× 106), the IC50 of sorafenib tosylate is 2.09μg/ml.  
Raf is a mitogen-stimulated protein kinase that functions as a component of the signaling cascade that leads to the stimulation of mitogen-activated protein kinase.
Vascular endothelial (VEGF) is a highly specific mitogen for vascular endothelial cells.
Treatment with nexavar potently inhibited the cell proliferation of MV4-11 cells (FLT3-ITD) in a dose-dependent manner with an IC50 of 0.88 nM. In MV4-11 cells, sorafenib tosylate of a concentration of 100 nM induced 43.6±5.2% of the cells to undergo apoptosis whereas in EOL-1 cells a concentration as low as 10 nM induced 89.29±1.8% of the cells to be apoptotic.
Nude rats at the age of 6 weeks injected with 105 MDA-MB-231 cells were involved. After monotherapy with sorafenib tosylate a significant reduction of the osteolytic lesion volume was observed on days 45 and 55 and of the soft tissue component volume on day 55 in comparison to untreated animals (p < 0.05). Compared to controls, treatment with sorafenib tosylate made bone metastases show significantly decreased values of Amplitude A and kep from day 35 to 55 (Amplitude A: p<0.01; kep p<0.01 on days 35 and 55; p<0.05 on day 45)

Other Hot-selling products
 
Popular Steroid  
1 Testosterone Enanthate CAS: 315-37-7  
2 Testosterone Acetate CAS: 1045-69-8  
3 Testosterone Propionate CAS: 57-85-2  
4 Testosterone Cypionate CAS: 58-20-8  
5 Testosterone Phenylpropionate CAS: 1255-49-8  
6 Testosterone Isocaproate CAS: 15262-86-9  
7 Testosterone Decanoate CAS: 5721-91-5  
8 Testosterone Undecanoate CAS: 5949-44-0  
9 Sustanon 250    
10 1-Testosterone Cypionate    
11 Turinabol CAS: 855-19-6  
12 Oral Turinabol CAS: 2446-23-3  
13 Stanolone CAS: 521-18-6  
14 Nandrolone Decanoate (DECA) CAS: 360-70-3  
15 Nandrolone Cypionate  CAS: 601-63-8  
16 Nandrolone Phenypropionate (NPP) CAS: 62-90-8  
17 Boldenone Acetate CAS :2363-59-9  
18 Boldenone Undecylenate (Equipoise)  CAS: 13103-34-9  
19 Drostanolone Propionate (Masteron)  CAS: 521-12-0  
20 Drostanolone Enanthate  CAS: 472-61-1  
21 Methenolone Acetate (Primobolan) CAS: 434-05-9  
22 Methenolone Enanthate  CAS: 303-42-4  
23 Trenbolone Acetate CAS: 10161-34-9  
24 Trenbolone Enanthate     
25 Trenbolone Hexahydrobenzyl Carbonate CAS: 23454-33-3  
26 Epiandrosterone  CAS: 481-29-8  
 
Oral Steroid
 		  
27 Anavar CAS: 53-39-4  
28 Anadrol CAS: 434-07-1  
29 Winstrol CAS: 10418-03-8  
30 Dianabol CAS: 72-63-9  
31 Superdrol CAS: 3381-88-2  
 
Anti-Estrogen
 
32 Tamoxifen Citrate (Nolvadex)  CAS: 54965-24-1  
33 Clomiphene Citrate (Clomid) CAS: 50-41-9  
34 Toremifene Citrate (Fareston) CAS: 89778-27-8  
35 Femara CAS: 112809-51-5  
36 Aromasin CAS: 107868-30-4  
37 Proviron CAS: 1424-00-6  
38 Arimidex CAS: 120511-73-1  
39   CAS: 566-48-3  
40 Cabergoline (Caber) CAS: 81409-90-7  
41 Finasteride CAS: 98319-26-7  
42 Dutasteride  CAS: 164656-23-9  
 
SARM
 		  
43 Ostarine (MK-2866) CAS: 841205-47-8  
44 Cardarine (GW-501516) CAS: 317318-70-0  
45 Andarine (S4) CAS: 401900-40-1  
46 Ligandrol (LGD-4033) CAS: 1165910-22-4  
47 Ibutamoren (MK-677) CAS: 159752-10-0  
48 RAD140 CAS: 118237-47-0  
49 SR9009 CAS: 1379686-30-2  
50 YK11 CAS: 431579-34-9  
 
Sex Enhancement
 		  
51 Avanafil CAS: 330784-47-9  
52 Vardenafil CAS: 224785-91-5  
53 Dapoxetine CAS: 119356-77-3  
54 Tadalafil CAS: 171596-29-5  
         
56 Vardenafil Hydrochloride CAS: 431579-34-9  
57 Dapoxetine Hydrochloride CAS: 431579-34-9  
58 Yohimbine Hydrochloride CAS: 65-19-0  
 
Pharmaceutical Intermediate
 		  
59 T3 CAS: 55-06-1  
60 T4 CAS: 51-48-9  
61 Ethyl Oleate(EO) CAS: 111-62-6  
62 Benzyl Alcohol (BA) CAS: 100-51-6  
63 Benzyl Benzoate (BB) CAS: 120-51-4  
64 Grape Seed Oil (GSO) CAS: 85594-37-2  
65      
66 1,3-Dimethylpentylamine (DMAA) CAS: 13803-74-2  
67 4-Acetamidophenol (Paracetamol) CAS:103-90-2  
68 Tauroursodeoxycholic Acid (TUDCA) CAS: 14605-22-2  
69 Dextromethorphan Hydrobromide (DXM) CAS: 6700-34-1  

Peptide List
 
Product Name Specification
ACE 031 1 mg/vial, 10 vials/kit
Follistatin 315 1 mg/vial, 10 vials/kit
Follistatin 344 1 mg/vial, 10 vials/kit
***************************** *****************************
MGF 2 mg/vial, 10 vials/kit
PEG - MGF 2 mg/vial, 10 vials/kit
DSIP 2 mg/vial, 10 vials/kit
TB500 2 mg/vial, 10 vials/kit
Oxytocin 2 mg/vial, 10 vials/kit
Hexarelin 2 mg/vial, 10 vials/kit
Triptorelin 2 mg/vial, 10 vials/kit
Ipamorelin 2 mg/vial, 10 vials/kit
Sermorelin 2 mg/vial, 10 vials/kit
Gonadorelin 2 mg/vial, 10 vials/kit
Tesamorelin 2 mg/vial, 10 vials/kit
BPC 157 2 mg/vial, 10 vials/kit
AOD-9604 2 mg/vial, 10 vials/kit
H 176-191 2 mg/vial, 10 vials/kit
CJC-1295 2 mg/vial, 10 vials/kit
CJC-1295 DAC 2 mg/vial, 10 vials/kit
***************************** *****************************
GHRP-2 5 mg/vial, 10 vials/kit
GHRP-6 5 mg/vial, 10 vials/kit
Selank 5 mg/vial, 10 vials/kit
***************************** *****************************
GHRP-2 10 mg/vial, 10 vials/kit
GHRP-6 10 mg/vial, 10 vials/kit
Epitalon 10 mg/vial, 10 vials/kit
PT-141 10 mg/vial, 10 vials/kit
Gonadorelin 10 mg/vial, 10 vials/kit
Melanotan II 10 mg/vial, 10 vials/kit
 

 
Packaging



99% High Purity Sorafenib Tosylate for Anticancer Drug CAS 475207-59-1





Shipping Method



99% High Purity Sorafenib Tosylate for Anticancer Drug CAS 475207-59-1






Company Information
Hubei Shinrezing Pharmaceutical Technology Co.,Ltd.(hereafter shorted as Shinrezing) is located in Wuhan Donghu High-Tech Economic Development Zone and established in 2008 with registered capital is RMB 10 million yuan (about USD 1.5 million ). Its manufacturing base is located in Dawu Industrial Park in Dawu County, Xiaogan City, Hubei Province which is built in 2010 with 25,000 square meters covered area.
 
Shinrezing is a rapid growing enterprise, which integrates the production, R&D, sales and trading of APIs, steroid raw materials, pharmaceutical intermediates, plant extracts, other kinds of organic intermediates etc. Shinrezing is not only a manufacturing company but also a trade company, it also has very good cooperation relationships with some manufacturers qualified with GMP, DMF to meet the different customers' needs from grams to tonnage quantity, which makes Shinrezing to be more flexible and easily to supply highly cost-effective products with high quality and better service to customers.
Shinrezing always stands in high starting, high stand and high quality, and masters strict management for production procedure and quality control. All the products must pass our quality test before being sending to customers. Shinrezing's products have been exported to more than 50 countries and regions all over the world, including United States, Europe, Japan, Korea, Russia, Hong kong, Taiwan and so on, and enjoy a good reputation from domestic and oversea customers
 
Shinrezing's mission is: "Innovative and Pragmatic, Mutual Benefits, Serve the World". Every staff member will keep this in mind all the time, and enforce it at every detail of operation and management of the company. We are always trying our best to offer the best services and the most compet