Product Name: GenisteinÂ
Synonyms: 4',5,7-trihydroxy-isoflavon;5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;c.i.75610;differenola;genistein(synthetic);genisteol;genisterin;prunetolÂ
CAS: 446-72-0
MF: C15H10O5Â
MW: 270.24Â
EINECS: 207-174-9
Product Categories: pharmacetical;Biochemistry;Flavonoids;Natural Plant Extract;The group of Daidzin;Inhibitors;Tyrosine Kinase Inhibitors;Protein Kinase;Signalling;Plant extract;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;inhibitor
Melting point : 297-298 °C
Storage temp. :Â Keep in RT.
Chemical Properties :Â Yellow Crystalline SolidÂ
Usage :Â Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal grow fact receptor kinase (IC50 -Â 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol .
Usage : Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or with IC50 of 19 μM.Â
Usage :Â cytotoxic inhibitor of tyrosine kinase and topoisomerase II kinase .
Genistein DescriptionÂ
Genistein is one of the most abundant isoflavones in soy and is one of several known isoflavones. Isoflavones compounds, such as genistein and daidzein, are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Because of its similar structure to that of human estrogen it is also called a phytoestrogen. Genistein is a natural bioactive compound derived from legumes and has drawn because of its potentially beneficial effects on some human degenerative diseases. It has a weak estrogenic effect and is a well-known non-specific tyrosine kinase inhibitor at pharmacological doses .
Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. In adult animals, dietary genistein has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors .Â
Health Benefits Estrogenic effect
The estrogenic activity of genistein has been confirmed in many studies. Of all the isoflavones, genistein has the strongest estrogenic activity. The estrogenic effect of genistein may explain its protective action against osteoporosis and its possible effect on body weight reductions. Genistein is also used to ease menopause symptoms, such as hot flushes .
Antioxidant
Genistein is a strong antioxidant. Genistein removes damaging free radicals and reduces lipid peroxidation. Genistein increases the activity of other antioxidant enzymes such as glutathione peroxidase, superoxide dismutase and glutathione reductase. Studies have shown that genistein can also influence the growth of cells which are not hormone-dependent .
Anticancer
Genistein seems to reduce the risk for some hormone related cancers, principally breast cancer and prostate cancer. Epidemiological studies show that consumption of isoflavones may protect against breast and prostate cancer. High dietary intake of soy products China and Japan are linked with low incidence of these cancers. There are lots of theories to explain the anti-cancer action of genistein: inhibition of angiogenesis, inhibition of tyrosine kinases, antioxidant property, and anti-estrogen action (it is known that estrogen increases risk for certain cancers). Genistein binds with estrogen receptors, preventing the estrogen from binding and initiating cancer growth.
Heart health
Many in-vitro tests have demonstrated that genistein inhibits cellular cholesterol synthesis and cholesterol esterification. Genistein also reduces fatty acid oxidation and exerts lipid lowering effect. Only oxidized LDL cholesterol is absorbed by the arterial cells and prevention of this oxidation will reduce the risk for arteriosclerosis. Gensistein prevents the formation of hearth attacks and strokes by acting as anticlotting agent .
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CAS 446-72-0 Natural Gorse Root Plant Extract Powder Anti-Tumor Genistein
Product Name: GenisteinÂ
Synonyms: 4',5,7-trihydroxy-isoflavon;5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;c.i.75610;differenola;genistein(synthetic);genisteol;genisterin;prunetolÂ
CAS: 446-72-0
MF: C15H10O5Â
MW: 270.24Â
EINECS: 207-174-9
Product Categories: pharmacetical;Biochemistry;Flavonoids;Natural Plant Extract;The group of Daidzin;Inhibitors;Tyrosine Kinase Inhibitors;Protein Kinase;Signalling;Plant extract;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;inhibitor
Melting point : 297-298 °C
Storage temp. :Â Keep in RT.
Chemical Properties :Â Yellow Crystalline SolidÂ
Usage :Â Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal grow fact receptor kinase (IC50 -Â 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol .
Usage : Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or with IC50 of 19 μM.Â
Usage :Â cytotoxic inhibitor of tyrosine kinase and topoisomerase II kinase .
Genistein DescriptionÂ
Genistein is one of the most abundant isoflavones in soy and is one of several known isoflavones. Isoflavones compounds, such as genistein and daidzein, are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Because of its similar structure to that of human estrogen it is also called a phytoestrogen. Genistein is a natural bioactive compound derived from legumes and has drawn because of its potentially beneficial effects on some human degenerative diseases. It has a weak estrogenic effect and is a well-known non-specific tyrosine kinase inhibitor at pharmacological doses .
Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. In adult animals, dietary genistein has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors .Â
Health Benefits Estrogenic effect
The estrogenic activity of genistein has been confirmed in many studies. Of all the isoflavones, genistein has the strongest estrogenic activity. The estrogenic effect of genistein may explain its protective action against osteoporosis and its possible effect on body weight reductions. Genistein is also used to ease menopause symptoms, such as hot flushes .
Antioxidant
Genistein is a strong antioxidant. Genistein removes damaging free radicals and reduces lipid peroxidation. Genistein increases the activity of other antioxidant enzymes such as glutathione peroxidase, superoxide dismutase and glutathione reductase. Studies have shown that genistein can also influence the growth of cells which are not hormone-dependent .
Anticancer
Genistein seems to reduce the risk for some hormone related cancers, principally breast cancer and prostate cancer. Epidemiological studies show that consumption of isoflavones may protect against breast and prostate cancer. High dietary intake of soy products China and Japan are linked with low incidence of these cancers. There are lots of theories to explain the anti-cancer action of genistein: inhibition of angiogenesis, inhibition of tyrosine kinases, antioxidant property, and anti-estrogen action (it is known that estrogen increases risk for certain cancers). Genistein binds with estrogen receptors, preventing the estrogen from binding and initiating cancer growth.
Heart health
Many in-vitro tests have demonstrated that genistein inhibits cellular cholesterol synthesis and cholesterol esterification. Genistein also reduces fatty acid oxidation and exerts lipid lowering effect. Only oxidized LDL cholesterol is absorbed by the arterial cells and prevention of this oxidation will reduce the risk for arteriosclerosis. Gensistein prevents the formation of hearth attacks and strokes by acting as anticlotting agent .
 More products you may like
Sulbutiamine CAS 3286-46-2
Aniracetam CAS 72432-10-1
Noopept CAS 157115-85-0
Idra-21 CAS 22503-72-6
4-Aminobutyric acid CAS 56-12-2
NSI-189 Free Base CAS 1270138-40-3
NSI-189 Phosphate CAS 1270138-41-4
9-fluorenol CAS 1689-64-1
Coluracetam CAS 135463-81-9
Sunifiram CAS 314728-85-3
Pramiracetam
Piracetam CAS 7491-74-9
Oxiracetam CAS 62613-82-5
Fasoracetam
Nefiracetam CAS 77191-36-7
Centrophenoxine CAS 3685-84-5
Pikamilon Sodium CAS 62936-56-5
PRL-8-53 HCL CAS :Â 51352-87-5
Levodopa(L-DOPA) CAS :Â 59-92-7
Etiracetam(UCB-6474) CAS :Â 33996-58-6
CAS 446-72-0 Natural Gorse Root Plant Extract Powder Anti-Tumor Genistein
Model NO.: 446-72-0
CAS: 446-72-0
Appearance: Yellow Crystalline Solid
Express Way: EMS, FedEx, TNT, DHL, Hkems
Alias: Genistein
Trademark: WHSO
Transport Package: 25kg/Drum
Specification: 1kg/25kg/package
Origin: China
HS Code: 121425246
Model NO.: 446-72-0
CAS: 446-72-0
Appearance: Yellow Crystalline Solid
Express Way: EMS, FedEx, TNT, DHL, Hkems
Alias: Genistein
Trademark: WHSO
Transport Package: 25kg/Drum
Specification: 1kg/25kg/package
Origin: China
HS Code: 121425246
CAS 446-72-0 Natural Gorse Root Plant Extract Powder Anti-Tumor Genistein