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Eplerenone Powder for Treat High Blood Pressure (107724-20-9)
Product Name: EplerenoneÂ
Synonyms: (7A,11A,17A)-9,11-EPOXY-17-HYDROXY-3-OXO-PREGN-4-ENE-7,21-DICARBOXYLIC ACID G-LACTONE METHYL ESTER;EPLERENONE;EPLERINONE;pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester;EPLERENONE 98%;EPLERENONE USP STANDARD;Elperenone;EplerenoneC24H3006Â
CAS: 107724-20-9Â
MF: C24H30O6Â
MW: 414.49Â
Chemical Properties White SolidÂ
Usage :Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.Â
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Usage Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM. It is used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spironolactone, though it may be more specific for the mineralocorticoid receptor.Â
Usage anticancer agentÂ
Biological Activity Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo .
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USE:Efficacy:As new therapeutic agents in the treatment of hypertension and other cardiovascular disease.For high blood pressure, heart failure, myocardial infarction, kidney disease and atherosclerosis has certain treatment function.