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Topiramate-----------Quick Details
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Topiramate Product Name: Topiramate
Topiramate CAS: 97240-79-4
Topiramate MF: C12H21NO8S
Topiramate MW: 339.36
Topiramate EINECS: 200-659-6
Topiramate Product Categories: Active Pharmaceutical Ingredients;APIs;Health &Â Beauty;Carbohydrates &Â Derivatives;Pharmaceuticals;Glutamate receptor;Intermediates &Â Fine Chemicals;API;TOPAMAX;Pharmaceutical raw materials
Topiramate Melting point : 125°C
Topiramate Storage temp. : 2-8°C
Topiramate Chemical Properties :Â White-to-Off-White Crystalline Powder
Topiramate Usage :Â anticonvulsant, antimigraine, GABA-A agonist, AMP/kinate glutamate receptor antagonist, carbonic anhydrase inhibitor
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Topiramate-----------Description
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Topiramate is an anticonvulsant (antiepilepsy) drug. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for Weight Loss. The drug had previously been used off-label for this purpose.
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Topiramate was originally produced by Ortho-McNeil Neurologics and Noramco, Inc., both divisions of the Johnson &Â Johnson Corporation. This medication was discovered in 1979 by Bruce E. Maryanoff and Joseph F. Gardocki during their research work at McNeil Pharmaceutical.
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Topiramate COA
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Items
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Specifications
 Results
Appearance
White to off-white powder, Freely soluble in dichloromethane
White powder, Freely soluble in dichloromethane
Identification
Infared Absorption
Complies
The retention time of the major peak in the chromatogram of the Assay prepration corresponds to that in the chromatogram of the standard preparation, as obtained in the assay
complies
Specific rotation
Between -28.6°and -35.0°, measured at 20°
-32.8°
Water
not more than 0.5%
0.12%
residue on ignition
not more than 0.2%
0.11%
Heavy metals
not more than 0.001%
complies
related compounds by HPLC(Test1)
Fructose not more than 0.3% Compound AÂ not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5%
Fructose: 0.03%
Compound A:0.04%individual impurity Total impurities: 0.07%
Particle size
90% less than 350 microns
complies
Limit of sulfamate and sulfate
Sulfamate ion not more than 0.10% Sulfate ion not more than 0.10%
complies
Residual Solvent
Methylene Chloride not more than 250μg/g
not detected
Acetone not mor than 2500μg/g Isopropanol not more than 5000μg/g Ethanenitrile not more than 400μg/g n-hexane not more than 290μg/g Ethyl Acetate not more than 2500μg/g Pyridine not more than 100μg/g
Assay
Topiramate contains not less than 98.0% and not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis
99.80%
Conclustion
The material complies with respect to USP35
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Topiramate Medical uses
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Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. In children, it is indicated for the treatment of Lennox-Gastaut syndrome, a disorder that causes seizures and developmental delay.
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Topiramate is also Food and Drug Administration (FDA) approved for, and most frequently prescribed for, the prevention of migraines. The drug is also used to treat migraines due to the effect it has on the blood vessels in the brain. It has been found to be increasingly effective for migraine sufferers with limited side effects .
--- Why Us --
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Quality assurance
With our years of experience , advanced technology and continuous research , our quality is to fully meet the needs of the market to meet the requirements of customers , many customers use our products , we believe that the product is very good . Whether it is a powder , or liquid , yes, we all know , our liquid better .
Safe transportation
Our mode of transport is taken according to each country's situation is different transportation , while our packaging , according to the latest customs situation , constantly updated , improved our packaging , we guarantee that you receive it within 3-5 to your product .
The product diversity
Our products are powders and liquids , yes , brothers , the effect of the liquid is very good , but many people do not use liquid , so you are very lucky, you buy our powder , we can tell you the method of making the liquid If you buy a liquid , we will tell you how to filter . We absolutely guarantee that you can very safely use our products .
Â
Topiramate-----------Quick Details
Â
Topiramate Product Name: Topiramate
Topiramate CAS: 97240-79-4
Topiramate MF: C12H21NO8S
Topiramate MW: 339.36
Topiramate EINECS: 200-659-6
Topiramate Product Categories: Active Pharmaceutical Ingredients;APIs;Health &Â Beauty;Carbohydrates &Â Derivatives;Pharmaceuticals;Glutamate receptor;Intermediates &Â Fine Chemicals;API;TOPAMAX;Pharmaceutical raw materials
Topiramate Melting point : 125°C
Topiramate Storage temp. : 2-8°C
Topiramate Chemical Properties :Â White-to-Off-White Crystalline Powder
Topiramate Usage :Â anticonvulsant, antimigraine, GABA-A agonist, AMP/kinate glutamate receptor antagonist, carbonic anhydrase inhibitor
Â
Â
Topiramate-----------Description
Â
Topiramate is an anticonvulsant (antiepilepsy) drug. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss. The drug had previously been used off-label for this purpose.
Â
Topiramate was originally produced by Ortho-McNeil Neurologics and Noramco, Inc., both divisions of the Johnson &Â Johnson Corporation. This medication was discovered in 1979 by Bruce E. Maryanoff and Joseph F. Gardocki during their research work at McNeil Pharmaceutical.
Â
Topiramate COA
Â
Items
Â
Specifications
 Results
Appearance
White to off-white powder, Freely soluble in dichloromethane
White powder, Freely soluble in dichloromethane
Identification
Infared Absorption
Complies
The retention time of the major peak in the chromatogram of the Assay prepration corresponds to that in the chromatogram of the standard preparation, as obtained in the assay
complies
Specific rotation
Between -28.6°and -35.0°, measured at 20°
-32.8°
Water
not more than 0.5%
0.12%
residue on ignition
not more than 0.2%
0.11%
Heavy metals
not more than 0.001%
complies
related compounds by HPLC(Test1)
Fructose not more than 0.3% Compound AÂ not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5%
Fructose: 0.03%
Compound A:0.04%individual impurity Total impurities: 0.07%
Particle size
90% less than 350 microns
complies
Limit of sulfamate and sulfate
Sulfamate ion not more than 0.10% Sulfate ion not more than 0.10%
complies
Residual Solvent
Methylene Chloride not more than 250μg/g
not detected
Acetone not mor than 2500μg/g Isopropanol not more than 5000μg/g Ethanenitrile not more than 400μg/g n-hexane not more than 290μg/g Ethyl Acetate not more than 2500μg/g Pyridine not more than 100μg/g
Assay
Topiramate contains not less than 98.0% and not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis
99.80%
Conclustion
The material complies with respect to USP35
Â
Topiramate Medical uses
Â
Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. In children, it is indicated for the treatment of Lennox-Gastaut syndrome, a disorder that causes seizures and developmental delay.
Â
Topiramate is also Food and Drug Administration (FDA) approved for, and most frequently prescribed for, the prevention of migraines. The drug is also used to treat migraines due to the effect it has on the blood vessels in the brain. It has been found to be increasingly effective for migraine sufferers with limited side effects .
--- Why Us --
Â
Quality assurance
With our years of experience , advanced technology and continuous research , our quality is to fully meet the needs of the market to meet the requirements of customers , many customers use our products , we believe that the product is very good . Whether it is a powder , or liquid , yes, we all know , our liquid better .
Safe transportation
Our mode of transport is taken according to each country's situation is different transportation , while our packaging , according to the latest customs situation , constantly updated , improved our packaging , we guarantee that you receive it within 3-5 to your product .
The product diversity
Our products are powders and liquids , yes , brothers , the effect of the liquid is very good , but many people do not use liquid , so you are very lucky, you buy our powder , we can tell you the method of making the liquid If you buy a liquid , we will tell you how to filter . We absolutely guarantee that you can very safely use our products .
Factory Direct Hote Supply Topiramate CAS 97240-79-4
Model NO.: 97240-79-4
Appearance: White Crystalloid Powder
Express Way: EMS, FedEx, TNT, DHL, Hkems
Trademark: ZSYH
Transport Package: Bottle
Specification: 99%
Origin: Hongkong
HS Code: 121425246
Model NO.: 97240-79-4
Appearance: White Crystalloid Powder
Express Way: EMS, FedEx, TNT, DHL, Hkems
Trademark: ZSYH
Transport Package: Bottle
Specification: 99%
Origin: Hongkong
HS Code: 121425246
Strong 99% Anticonvulsant Active Pharmaceutical Ingredients Topiramate CAS 97240-79-4