Scientists create artificial immune cells that can detect and kill cancer cells! December 08, 2016 Source: Bio Valley Researchers have developed an artificial structure that mimics the cell membrane and can "turn on" immune cells to attack and destroy a specific target. In the future, this approach may be used as a cancer immunotherapy and provide a deeper understanding of how immune cells are activated to detect and kill cancer cells. The findings were published today at a joint meeting of the British and Dutch Immunology Associations. The conference was held in Liverpool, England. Immunotherapy is the body's own immune system to attack cancer cells, which is the most promising new form of cancer treatment. For these effective immunotherapies, we need to understand how the immune system recognizes cancer cells and responds to cancer cells. This requires antigen presenting cells (APCs) to present proteins (or antigens) on tumor cells. Antigen-presenting cells are a group of immune cells that coordinate the immune response. PhD student Loek Eggermont and the research team from the figdor laboratory at the Radboud University Medical Center in the Netherlands solved this problem by developing artificial antigen presenting cells. They developed a filamentous polymer scaffold with a specific structure that mimics the cell membrane of antigen presenting cells. This scaffold is inlaid with a variety of different T cell activating proteins. In in vitro studies, they found that these artificial antigen presenting cells are capable of activating human T cells, their effects on proliferation and differentiation. They also found that different receptors on T cells must be close to each other through artificial antigens on them, and T cells can achieve optimal activation. These findings help us better understand the mechanisms by which T cells activate, that is, what signals these cells need to start attacking cancer cells, and provide a promising approach to developing more effective immunotherapy. The group's current goal is to make this polymer more specific for cancer proteins, allowing it to induce T cells to attack only cancer cells. After that, you need to test the system. As a first assessment, the mouse model assesses whether it can be used to effectively treat cancer in the body. A researcher at the Radboud University Medical Center said: "Cancer immunotherapy relies heavily on the proper activation of immune cells, such as T cells, to detect and destroy tumor cells. Currently, immunotherapy relies on non-specific immune systems to fight cancer. Activation." "We have shown in in vitro studies that artificial antigen presenting cells can effectively activate T cells. Our findings also help us better understand the mechanisms behind this T cell activation. Although more research is needed Find out if this system works in animal models, and we hope that one day it will bring new developments in cancer immunotherapy."
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