Canned Sardine is made of sardines and
tomato sauce, is common canned food, the production is complex. The
ingredients are from our company ocean going ships, we going sea fishing,
directly sea-frozen, then returned to the factory for production, processed
into canned sardines. We have variety of tasty, including Canned Sardine in
Brine, Canned Sardine in Tomato Sauce, Canned Sardine In Sunflower Oil, Canned
Tuna in Vegetable Oil.
Canned fishes are made in our sub company-Zhejiang
XingWang LongSheng Food Co.,Ltd. The company now has two factories(can branch
and loin branch) and the main production equipment are: 3 processing capacity
of 60 mt(materials)/day canned fish production lines; 4 processing capacity of
50 mt(materials)/day frozen cooked tuna loin production lines; 3 freezing
capacity of 80 mt/day freezer rooms and 1 disposing capacity of 1000m³/day
waste-water treatment plant. All the key equipment of every plant are imported
from Thailand or Japan.
We will always strive to create more
delicious, natural and safer marine health food.
Canned Sardine Canned Sardine,Canned Sardine In Brine,Canned Sardine In Sunflower Oil,Canned Sardine In Vegetable Oil TAIZHOU XINGWANG AQUATIC PRODUCT CO., LTD. , https://www.tzxingwang.com
2. Production process of cold-drying preparations Genetically engineered peptides and protein drug lyophilized preparations are obtained by culturing a host (microorganism or animal cell) to obtain an expression product! The active substance is obtained by separation and purification, and is prepared, filtered, and dispensed, and packaged. The sample is sent to the freeze dryer for pre-freezing! Sublimation! Drying, sealing after the Zui "Therefore the production process of the lyophilized preparation includes drug preparation! Pre-freezing! One drying (sublimation drying) and secondary drying (desorption drying)! Sealing Save 5 steps, etc. The details will be explained below.
For the development of new products, it is necessary to determine the lyophilization process conditions through experiments. After the drug is prepared, the eutectic point of the aqueous drug solution is determined. The eutectic point is important for freeze-drying because the liquid is a complex liquid. When the temperature drops to a certain temperature, the crystal begins to precipitate. As the temperature drops, the number of crystals increases. After the Zui, all the condensation occurs. At this time, the temperature is called the coagulation point. If the temperature rises from the freezing state to the coagulation point, the melting starts, and the solute starts. And the eutectic point of the solvent. Different materials have different eutectic points, such as 0.85% sodium chloride solution -21.2 ° C, and 10% glucose solution is -27 ° C eutectic point measurement by thermal analysis method; resistance method and direct observation by low temperature microscope. The thermal analysis method is based on the freezing of the drug during the heating process, when the temperature reaches the eutectic point, there will suddenly be an absorption of energy. The thermal absorption meter can be used to determine the energy absorption peak to calculate the eutectic temperature; the resistance method is to cool down or After the freezing, the resistance suddenly becomes larger or smaller, and the resistance change of the non-ionic organic compound is not obvious. A certain amount of additive can be added to determine that "freeze drying is carried out under vacuum, only the liquid After all freezing, it can be sublimated under vacuum. Otherwise, when some liquid is present, it will not only evaporate rapidly under vacuum, causing the liquid to concentrate, causing the freeze-dried product to shrink, and the gas dissolved in the water will quickly emerge under vacuum, resulting in The liquid boils and even emerges from the lyophilized bottle, so the temperature of the lyophilized product must be lower than the eutectic point when it begins to sublimate, and all freeze.
The freeze-drying time is generally long. In order to ensure product quality and shorten the production cycle, it is necessary to determine the freeze-drying curve through trial and error, because the freeze-drying effect is measured by the activity retention rate of the lyophilized preparation and the original liquid, and the activity preservation rate is It is related to the freeze-drying curve and the composition and ratio of the liquid. Therefore, it is necessary to repeatedly test to optimize and determine. Figure 2 is a schematic diagram of a freeze drying line.
Application of freeze-drying technology in genetic engineering drugs
Application of Freeze-Drying Technology Freeze-drying technology was invented by the British person Wallaston in 1813. The Shsckell test used this method to fight toxins in 1909! The strain! The rabies virus and other biological products were freeze-dried and preserved, and achieved good results. In the sub-world war, due to the large demand for blood products, freeze-drying technology has developed rapidly and entered the stage of industrial application. The large-scale development of freeze-dried food systems in the 1950s promoted the progress of freeze-drying technology and equipment, but due to the high Difficulty! High investment! High energy consumption and backwardness of manufacturing equipment have experienced decades of ups and downs. Over the past 20 years, with the improvement of people's living standards, the quality of food! Nutrition! Natural pollution-free concept change, promote The development of freeze-drying technology, the production process from batch to continuous, the equipment from 0.1m2 to thousands of m2 form a series, a wide range of applications: in scientific research, applied to the analysis of components such as soil analysis; removal of high performance liquid chromatography Solvents for collecting components; important cultural relics found in archaeology such as cloth! Leather, drying and dehydration of bamboo slips, etc. "In the industry, applied to freeze-dried foods such as vegetables! Fruits! Sea Products! Even flowers, etc.; spices and condiments such as coffee! Tea and various spices! Seasonings; convenience foods that preserve nutritious health ingredients and color and flavor (50% of Japanese convenience foods are freeze-dried foods); aquatic products "zui Wide range of requirements: Zui is strictly applied in medicine and biological products, mainly applied to serum! strains! Genetic engineering drugs! Vaccines! Natural medicines and biological products, etc. "National Biological Products Regulations 2000 Edition, 11 identified There are 8 recombinant therapeutic protein drugs, such as recombinant human interferon α1b! Recombinant human interferon α2b! Recombinant human interferon α2b! Recombinant human interferon γ! Recombinant human interleukin 22! Recombinant human erythropoietin! Human granulocyte macrophage colony-stimulating factor! Recombinant streptokinase.