breakthrough! Scientists identify new anti-cancer targets

breakthrough! Scientists identify new anti-cancer targets

September 13, 2016 Source: Bio Valley

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Recently, a research report published in the international journal Nature , researchers from the Icahn School of Medicine in Mount Sinai, USA identified a key protein that can be used as a novel Targets to help develop new cancer therapies, a protein called Ras Kinase Inhibitor (KSR), a special kind of enzyme that plays an important role in the intracellular signaling process that determines whether cells grow, divide or die. Role, the researchers pointed out that targeted KSR has a certain significance for the development of clinical therapy, which may improve the prognosis of many patients with malignant cancer, such as lung cancer and pancreatic cancer.

Ras is a frequently mutated human oncogene. Although recent research has made great progress, new therapeutic methods for targeting Ras-dependent cancer are still very limited. In previous studies, researchers' research supports the adoption of KSR. Targeting the possibility of Ras carcinogenic forms, but so far scientists have not reported on the progress of related pharmacological methods.

Researcher Professor Arvin Dar said that we have been looking for new drug targets for Ras-dependent cancer. Now we use known KSR genetic mutations to suppress the mutated Ras signal, which can guide us to develop new types. Cancer treatment compounds; in this study we applied a variety of different methods used in the chemical field to mimic specific genetic mechanisms that block the development and progression of Ras-dependent cancers.

The lead compound, APS-2-79, developed by the researchers in this study, regulates the Ras signaling pathway and increases the potential of various other cancer drugs in RAS-mutant cell lines. Dr. Dar said that KSR belongs to a family of proteins that not only participate in the development of cancer, but also directly related to the pathogenesis of other diseases. No one can really clarify how to develop these important drug targets, but this research may open up a new way to study this. In the future, we may be able to help develop new cancer therapies and more potential by regulating KSR. Interventions.

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