Combination of two drugs is expected to effectively treat AIDS

Scientists at the University of Minnesota Medical Center said recently that they have found that the two drugs that are approved by the US Food and Drug Administration for the early use of cancer and cancer treatment, decitabine and gemcitabine, are expected to be effectively treated. AIDS. In the animal model study of experimental mice, mixed drugs can cause HIV to mutate and die. Scientists call it a "lethal variation."

The new discovery has epoch-making significance for AIDS research, because it is the first time people have found a way to deal with HIV without toxic side effects. Scientists believe that because cytidine and Glycerine are two approved drugs, if their results are valid in large experimental animal models, it will be easier to accelerate the development of drugs suitable for humans.

Research participants included molecular virologists Dr. Luis Manski and Dr. Christine Crowther of the Molecular Viral Institute and the School of Dentistry, and Dr. Steven Patterson, a drug chemist at the Center for Drug Design. Manski said that their findings have brought hope to eventually help the 33 million people around the world with HIV to relieve their illnesses.

HIV mutates and evolves rapidly in the human body. The main role of drugs currently used is to inhibit the growth and replication of viruses. The effect of new drugs consisting of cytidine and octase is just the opposite. It forces the virus to mutate out of control and die. Manski said that the ability of HIV to mutate makes it difficult for people to catch and deal with it. "We have used this behavior of the virus to make the virus itself attack itself as a weapon by promoting the mutation rate of the virus."

Scientists have found that the concentration of the drug they use to kill the HIV virus has no detectable toxicity to cells. At the same time, the concentration of drugs used to effectively kill lab-grown HIV is much lower than that of people. The drug concentration in the treatment of cancer. The existing approved use of drugs has been used to develop methods for treating other diseases. It is considered in the medical community to be a low-cost and fast-track method for acquiring new drugs, which is called drug repositioning.

It is reported that cytidine and Ginseng have been allowed to conduct pre-clinical experiments in experimental mice. The initial findings confirmed that the drug can be used as an effective antiviral therapy for HIV. At present, scientists are adjusting drugs to form anti-HIV oral drugs that can be absorbed by the body.