Release date: 2018-05-29 The Japan Institute of Physical Chemistry and Hiroshima University recently announced that their joint research team conducted a genome analysis of hepatitis B virus (HBV) infection in the liver, and discovered the mechanism by which hepatitis B virus is embedded in the human genome and part of the mechanism of viral carcinogenesis. About 350 million people worldwide are infected with hepatitis B virus, and about 880,000 people die every year from hepatitis B virus. Hepatitis B virus infection has limited treatment methods, mainly using interferon and nucleic acid mimicking preparations. It not only requires long-term medication, but also has side effects and virus resistance. The treatment effect is not satisfactory. Most patients will still switch from hepatitis B virus infection to chronic hepatitis. And liver cancer. It is generally believed that after infection with hepatitis B virus, hepatitis B virus genome insertion occurs in human hepatocyte genes and develops into liver cancer. The team tested DNA extracted from hepatitis B virus-infected patients and adjacent liver tissue and hepatitis B virus-infected mouse models, and analyzed more than 1600 embedded sites in detail. The results showed that in the mouse model of infection from 3 weeks to 7 weeks, the hepatitis B virus gene was mainly concentrated in the mitochondrial gene; in human liver cancer and adjacent liver tissue, each sample was programmed into 1279 loci, and the genomic embedding site was mostly located in staining. Open area. In liver cancer, a specific cancer-related gene is incorporated, which is considered to contribute to canceration. In addition, the team also confirmed the expression of hepatitis B virus and human fusion genes, and speculated that this is related to hepatitis B virus infection and cancer. This study demonstrates the mechanism by which hepatitis B virus embeds human genes, and is expected to contribute to the development of new therapeutic drugs, preventive methods, and new viral therapeutics targeting mitochondria. The research results were recently published online in the journal Oncotarget. Source: Technology Daily Ventilation is one of the most important components in a successful greenhouse. Circulation Fan,Greenhouse Ventilation Fan,Automated Greenhouse Ventilation Fan JIANGSU SKYPLAN GREENHOUSE TECHNOLOGY CO.,LTD , https://www.greenhousehydroponic.com
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