Metal-free implants can reach the vascular wall balloon and can also take medicine for coronary heart disease

Release date: 2018-07-13

After 6 years of research and development, China's independent innovation and research and development, the first internationally approved light cane drug balloon for coronary artery bifurcation treatment, recently held in Shanghai Medical Association, Shanghai Medical Association Cardiovascular Disease Branch, the twelfth The Eastern Cardiology Conference was widely acclaimed. The experts believe that the product is stable in drug loading and has high bioavailability. The coating process ensures rapid and uniform release of the drug to the lesion. A short-term exposure (30 seconds to 60 seconds) can effectively inhibit the endothelium. Proliferation provides a new treatment for the treatment of clinically needed bifurcation lesions. Currently, the product has been approved for marketing.

It is reported that coronary bifurcation lesions refer to lesions with severe stenosis in the main branch and branch of the coronary artery, respectively, accounting for 15% to 20% of all percutaneous coronary interventions. It has been a difficult point in coronary intervention. According to experts, percutaneous coronary intervention has been used for several generations of drug-eluting stents, significantly reducing the incidence of restenosis within 1 year after vascular lesions, but the side effects caused by drug-eluting stent placement are also Not effectively addressed, such as the polymer and metal stent itself can cause chronic inflammation, late stent thrombosis, advanced restenosis, long-term use of anticoagulant drugs, and the loss of local vascular physiological function. The canoe drug balloon has created a new treatment concept of “interventional non-implantation” for coronary intervention, that is, the anti-proliferative drug (paclitaxel) carried on the surface is released into the blood vessel wall by balloon expansion, inhibiting the proliferation of vascular smooth muscle cells and intimal hyperplasia. . The procedure is free of metal implants and polymer residues, which helps to reduce thrombosis in patients and avoids a series of negative problems caused by long-term implants.

Ge Junbo, an academician of the Chinese Academy of Sciences and director of the Department of Cardiology of Zhongshan Hospital affiliated to Fudan University, said that when he talked about the development and prospects of cardiac stents and drug balloons, he said that the drug balloon would completely replace the stent, but it is certain that the drug balloon will With its own stage, it can provide new treatment strategies for clinically needed bifurcation treatment. (Reporter Sun Guogen)

Source: Health News

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