New brain cells found in the cerebral cortex are axonal like rose hips or unique to humans and primates

New brain cells found in the cerebral cortex are axonal like rose hips or unique to humans and primates

August 29, 2018 Source: Science and Technology Daily

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Science and Technology Daily, Washington, August 27 (Reporter Liu Haiying) A research team at the Allen Institute of Brain Science published a paper in the journal Nature Neuroscience on the 27th that they discovered a new type of brain cell, although it has not been proven. It is unique to humans but has never been seen in rodents such as mice.

This brain cell is found in the human cerebral cortex and is a special type of human cerebral cortex GABAergic nerve cell. Because of its large "rose corolla"-like axon final buckle and tight dendritic structure, the dense bundle of axons formed around the center of the cell looks like a rose after the petal has fallen off, so the researchers call it For "Rosehip nerve cells."

Transcriptomics analysis and morphological student physiology studies have shown that the cells belong to inhibitory neurons. Inhibitory nerve cells act to brake the activity of other nerve cells in the brain, while rose hip nerve cells are thought to provide effective local control of distal dendritic calculations in cerebral cortex pyramidal neurons.

Although it has not been proven that this brain cell is unique to humans, the researchers said that they have never seen such nerve cells in rodents such as mice, which may exist only in human or primate brains. Specialized nerve cells. It is precisely because there is no such cell in the mouse brain, so it is unlikely that the simulation study will be carried out through animal experiments, and only the human brain sample can be used, which will undoubtedly make the future in-depth research more difficult.

At present, researchers have not fully understood the role of these specialized cells in the human brain, and it is not clear whether it will change during human disease. They next plan to look for such cells in other parts of the brain and explore their potential role in the brain.

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