New nano-simulation technology blocks malaria

Plasmodium can invade human red blood cells and interfere with the normal function of cells. Recently, scientists from the University of Basel and other places have developed a miniature nanostructure that can "spoof" Plasmodium to mimic human cell membranes. Related research published in the international magazine ACS Nano The study may help develop new therapies and vaccines for the treatment of malaria and other infectious diseases.

Researcher Wolfgang Meier said that the use of nano-simulation technology can interrupt the normal cycle of Plasmodium. In this paper, we designed and tested the performance of this host cell membrane nano-simulated structure. To develop this simulated cell membrane, the researchers also devised a novel step to make small artificial bubbles that can act as cell receptors on the cell surface, and such multimeric vesicles carrying water-soluble host receptors The bubbles can be prepared by a mixture of two different agglomerated copolymers which can be spontaneously assembled in aqueous solution.

Normally, Plasmodium can destroy the function of host red blood cells 48 hours after entering the body, and then continue to infect new red blood cells. In the infection stage, the malaria parasite must bind to specific host cell receptors, and the researchers developed nano cell membrane structures. It can then bind to the Plasmodium that flows out of the cell, thereby blocking its invasion into other uninfected cells.

In this study, researchers used fluorescence and electron microscopy to detect the interaction of nanocellular membranes with Plasmodium. The researchers said that this nano-simulated structure is reducing malaria infection compared to water-soluble cellular receptors. It is 100 times that of the former; in other words, in order to block the infection of Plasmodium, it is necessary to use 100-fold concentration of water-soluble receptors to completely block.

Finally, the researchers say that this study provides new research ideas and hopes for the development of new alternative therapies and vaccines for the treatment of malaria. Since many other pathogens currently use the same cellular receptors for invasion, researchers have developed The new nano-simulation technology will help treat other more infectious diseases.

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