Science Supplement: This bacterium can prevent skin cancer March 5, 2018 Source: Biological Exploration of: M Kee In a study published in the journal Science Advances on February 28, researchers at the University of California, San Diego School of Medicine said that some bacteria on the skin have a new role in cancer prevention. Source: UC San Diego Health In the United States, more than 1 million people are diagnosed with skin cancer each year, and more than 95% of them are non-melanoma skin cancers, which are usually caused by excessive exposure to the sun's ultraviolet rays. Dr. Richard Gallo, a professor of dermatology at the San Diego Medical School, said, "We have discovered a S. epidermidis strain that is commonly found on healthy human skin and selectively inhibits the growth of certain cancers." The team found that Staphylococcus epidermidis produces a molecule that inhibits DNA polymerase activity, 6-N-hydroxyaminopurine (6-HAP). To test the function of 6-HAP, the researchers injected a 6-HAP intravenously into the mice over a two-week period. As a result, 6-HAP inhibited the growth of melanoma with no significant systemic toxicity. When melanocytes were introduced into mice, the tumor size in mice receiving intravenous 6-HAP was inhibited by more than 50% compared with mice that did not receive injection. DOI: 10.1126/sciadv.aao4502 In mice with epidermal grape globules but no 6-HAP molecules on the skin, the number of tumors increased after exposure to carcinogenic ultraviolet light. However, this was not the case for mice with S. epidermidis strains and producing 6-HAP molecules. The researchers found 6-HAP strains in a number of healthy human subjects, suggesting that some individual microbial communities may have protective effects on skin cancer. These findings suggest that skin commensal bacteria play a new role in host defense. Gallo said, “There is increasing evidence that the skin microbiome is an important part of human health. For Staphylococcus epidermidis, it also seems to add a layer of protection to certain cancers.†Next, the Gallo team will further investigate how 6-HAP is produced, whether it can be used to prevent cancer, or whether the loss of 6-HAP increases the risk of cancer. References: 1)Beneficial skin bacteria protect against skin cancer We're professional Orthopedics Instruments
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