The Chinese Academy of Sciences research team found a new mechanism to inhibit tumor cell growth July 10, 2018 Source: People's Daily Author: Wu Yuehui Cancer is one of the world's leading causes of death. Its main feature is the uncontrolled growth of tumor cells. Its rapid growth requires a lot of energy. Previously, British scientists have found that NF-kappa-B protein plays an important role in the process of acquiring energy from tumor cells. If it inhibits the function of this protein, it will increase the possibility of inhibiting cancer cells. Later, some German scientists discovered that by adjusting the diet, reducing glucose intake, cancer cells that depend on sugar for a long time will die rapidly under a continuous low-sugar diet. However, is the fact really so simple? of course not! In the first case, the NF-kappa-B protein is inhibited by the drug, and the energy conversion channel is blocked, which may inhibit the spread of some cancer cells, but if the application is not accurate, the healthy cells will be killed and spread. Cancer cells are even more difficult to search for. In the second case, many cancer patients have low immunity, and there is a low appetite in the process of chemotherapy. It is easy to keep up with nutrition. At this time, let them reduce the intake of sugar and starch, which may result in no Good consequences. So, is there any new way to go in the direction of inhibiting tumor cell growth? The research team led by Liu Hongwei, a research group of the Institute of Microbiology, Chinese Academy of Sciences, and Sun Chaoyu, a researcher at the Qingdao Institute of Oceanography of the Chinese Academy of Sciences, has continuously obtained a new anti-tumor lead molecule that can specifically block the energy supply of tumor cells. The study was published online today in the famous journal of Pharmacology, Nature, Cell Death and Disease. The growth of tumor cells requires a lot of energy, and they also require the participation of nucleic acids, fatty acids and amino acids. Tumor cells meet the needs of bioenergy and biosynthesis by modulating the metabolism of these important components. Among lipid metabolism and related metabolism, there is a protein called fatty acid binding protein, which plays a major role in the metabolic pathway. That is to say, anticancer drugs can treat diseases of the human body by acting on this protein. In 2014, Xiong Weiping, a researcher at the Vegetable Institute of the Tibet Academy of Agriculture and Animal Husbandry, first realized the artificial cultivation of Tibet's rare medicinal fungus, white meat, and carried out research on active ingredients in cooperation with the Chinese Academy of Sciences. A few days ago, the researchers of the Chinese Academy of Sciences research team used Tibetan Ganoderma lucidum as research material to separate and extract the novel triterpenoid compound GL22 from Tibetan Ganoderma lucidum. They found that GL22 can significantly inhibit the proliferation activity of liver cancer cells, and eventually cause the death of liver cancer cells, and it will not cause obvious toxic side effects on the body, effectively reducing the impact on normal cells, showing a comparative advantage in the field of anti-hepatocarcinoma drug development. Good application prospects. People's Daily (July 09, 2018, 18th edition)
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