"Xenograft treatment of type 1 diabetes has basically achieved similar efficacy to human islet transplantation. The team plans to work with multiple hospitals to achieve the goal of completing 10,000 diabetes treatments per year after two years of work." September 8 , Changsha, Hunan Provincial Medical Association organizes experts to review the “Clinical Study of Newborn Porcine Islet Transplantation for the Treatment of Small Diabetes Type 1 Diabetes†approved by the Hunan Provincial Health Department in 2013, Professor of the Third Xiangya Hospital of Central South University, Hunan Province Wang Wei, director of the Transplant Engineering Technology Research Center, said. This means that xenotransplantation is expected to enter the clinic, benefiting millions of ordinary patients. Diabetes is the "difficult" disease facing the world today, with hundreds of millions of patients. International research suggests that human islet transplantation is currently the treatment that may cure diabetes. However, human-derived organ donors are extremely scarce, and the number of donors for human islet transplantation is extremely limited. In order to break through the bottleneck of donor shortage in islet transplantation, Wang Wei team conducted a 21-year study of xenograft pig islets. Up to now, it has won a series of world-leading system original results: In Ningxiang, Hunan, the “Biosafety Donor Breeding Centerâ€, the second in the world and the number one in Asia, was established to raise and cultivate the medical-grade donor “Sino Pig†for pig islet transplantation. Established a world-leading large-scale high-efficiency porcine islet isolation and purification system and detection system, which can scale production, extract large quantities of porcine islets, and ensure the purity and activity of islets extracted; In the world, the clinical system of porcine islet transplantation for the treatment of diabetes was established for the first time, and a minimally invasive surgical plan to protect transplanted islets was designed. This program not only reduces the chance of complications, but also effectively prevents the bleeding clot from "eat" the islets that have been transplanted. Wang Wei said that the new clinical islet transplantation treatment program can also transfer the regulatory T cells from the patients while transplanting islets, significantly reduce the rejection of transplanted islets in patients, and greatly reduce postoperative anti-rejection drugs. The dosage used. Clinical results show that this innovative transplantation technology system is highly safe and effective. In this research project reviewed, Wang Wei team completed a study on porcine islet transplantation in 10 patients with type 1 diabetes. In these patients with severe disease, after transplantation of porcine islets, the condition improved significantly, blood sugar remained stable and normal, and glycated hemoglobin also recovered to the standard. Compared with preoperative, the overall insulin use was reduced by more than 60%, and the best effect was reduced by 90%. According to the internationally recognized islet comprehensive evaluation score, the average score is 0.62 points, preferably 0.88 points (1 point for complete cure of diabetes). The effect is much higher than the highest score of 0.17 points in Japanese porcine islet transplantation for diabetes research. According to the review experts, the project has established the complete technical system of “transplant donor culture-porcine islet extraction-clinical application†for the first time in the world. The technology has reached the international leading level and has reliable bio-safety. Source: Technology Daily Auto Chemistry Analyzer,Semi Auto Chemistry Analyzer,Veterinary Automatic Chemistry Analyzer,Dry Chemistry Analyzer Guangdong Widinlsa International Co.Ltd , https://www.guangdongwidinlsa.com