Release date: 2018-07-18 Recently, the team of Professor Guo Zheng of the Department of Orthopaedics of the Xijing Hospital of the Air Force Military Medical University successfully implanted a titanium alloy support rod with a gradient of human bone structure into the patient with necrosis of the femoral head, effectively relieving pain symptoms and improving joint function. According to the search, the clinical use of 3D printed bionic porous support rods for the treatment of femoral head necrosis is the world's first. The incidence of femoral head necrosis is high, early and mid-term intervention is critical Femoral head necrosis is one of the common and refractory chronic diseases in orthopedics. According to incomplete statistics, there are about 30 million patients with femoral head necrosis in China and about 4 million in China. The early stage of the disease is characterized by dull pain around the hip joint and aggravation after the activity. Further development may cause the femoral head to collapse, and eventually the artificial joint can only be replaced. Clinical intervention in the early and middle stages of femoral head necrosis, delaying or preventing the collapse of the femoral head is an important measure to protect the hip. In the past, the main intervention method for patients in the early and middle stages was to drill and decompress the femoral head. Although simple decompression can alleviate the pain symptoms, the lack of mechanical support in the necrotic area may accelerate the collapse of the femoral head. At present, porous rods are used for support in the world, but the therapeutic effect of porous rods has certain limitations. 8 years of innovative research and development of femoral head support rods In response to the extremely critical treatment characteristics of early and mid-term intervention of femoral head necrosis, Professor Guo Zheng began research on early and mid-term treatment of femoral head necrosis in 2010, in one national key research and development, two national 863 programs and four national natural science funds. With the support, a stable animal model of femoral head necrosis was successfully established, and more than ten kinds of support rods with different configurations and different materials were developed. Four national invention patents were obtained, and 11 related researches on porous support rods were published in international authoritative journals. The support rod developed by Professor Guo Zheng's team is innovative with a gradient-like human bone structure and a central tube design. The gradient-like human bone structure design can replace or share the femoral head weight-bearing function, so that patients can avoid femoral head collapse under normal walking conditions. It is beneficial to the growth of bone tissue and tightly combined with surrounding bones to increase mechanical properties. The central tube design can be used as a channel to maintain core decompression, or as a channel for injecting artificial bone or other osteoinductive active substances, so that the injected artificial bone or osteoinductive drug is concentrated in the necrotic area of ​​the femoral head, and promotes new bone formation. Repair the necrotic area. In vivo implantation of 3D printed support rods for minimally invasive treatment of femoral head necrosis Li Wei (pseudonym), a 42-year-old from Yulin, Shaanxi, developed pain in the left hip six months ago. He was significantly aggravated when he was squatting or tired. After coming to Xijing Hospital, the diagnosis was confirmed as bilateral femoral head necrosis. After consultation with the expert team, it was decided to apply a series of innovations to implant a titanium-like femoral head support rod. Before the operation, the Department of Orthopaedics of Xijing Hospital was jointly designed with Xi'an Dimensional Biotechnology and Shaanxi Dongwang Technology. According to the image data of the femoral head necrosis area, the digital individualized design and 3D printing of the human bone structure titanium alloy femoral head support rod. According to Prof. Fan Hongbin, the surgeon of this operation, the operation was minimally invasive and the implantation process was smooth. It took only 30 minutes to avoid joint replacement, achieving minimally invasive precision operation and saving surgery costs. On the day of surgery, the pain symptoms around the hip joints were significantly relieved, and the joint function recovered satisfactorily one week after surgery. It is reported that the 3D printing human bone titanium alloy femoral head support rod has won the national invention patent, providing a new program for the treatment of femoral head necrosis, and is expected to benefit more patients with femoral head necrosis in the near future. (Reporter Shi Junbin correspondent Ren Weifeng, Party Jing Gang) Source: Technology Daily
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