NEJM: Breakthrough technology for kidney transplantation - patients no longer need to wait for successful matching

Release date: 2016-03-15

In kidney transplant surgery, the most troublesome thing is to find a suitable donor. Due to the existence of immune rejection, in order to reduce the risk of organ rejection after surgery, it is best to find donors with very similar biological characteristics, which means that many kidney transplant donors are derived from relatives. Now a new technology allows patients to adapt to any donor kidney, which will greatly improve the cure rate of kidney patients.

The new technology was published in the latest issue of the Journal of New England Medicine and was reported by The New York Times. Experts say the foundation is revolutionary and will dramatically reduce the amount of time patients wait for donors. In particular, this technique can alter a patient's immune system and reduce their level of response to heterogeneous organs. The specific molecular mechanisms are currently unclear, but newer antibodies appear to be less "repulsive" to the foreign organs that are transplanted.

This process is called "desensitization" and has been practiced on a small scale before, but the recently reported article details the effect of this therapy.

Based on data from more than 2,000 patients in 22 clinical trials, 76.5% of desensitized patients survived healthy for 8 years after transplantation of exogenous kidneys, which is better than control patients (ie, no relevant treatment, some kidney transplantation) Some, still waiting for the list, 62.9% of the survival rate of 8 years or more should be significantly improved.

It takes a certain amount of time before the therapy is actually applied: first, the therapy is not officially approved, and the cost of this method is also very expensive ($30,000).

Currently, one-third of patients who need a kidney transplant cannot find a suitable match, and 100,000 patients in the US are on the waiting list. This therapy seems to be the only option for this group of patients.

"You don't have to wait for a perfectly fit living donor organ, you just need a living donor of any type," says Dr. Dorgy Segev, a researcher at Johns Hopkins University. Segev also believes that this technology can be used in other living organ transplants, such as the liver, lungs and so on.

Source: Bio Valley

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Vitamin K2 MK-7, Vitamin C, Vitamin E, Vitamin K2, Vitamin H, Vitamin D3

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