What is clinical precision medicine ? When it comes to precision medicine , what do you think of precision medicine first? Why is someone called precision medicine? Some people call precision medicine, some people call clinical precision medicine, and some people call clinical precision medicine? In fact, clinical precision medicine is able to understand the mechanism of disease at the molecular level, diagnose the nature of the disease at the molecular level, and design treatment plans for patients at the molecular level. This can make clinical treatment more precise, better, and fewer side effects. When it comes to precision medicine, I am very willing to introduce Zhongshan Hospital's attempt to develop precision medicine. At the end of 2014, we started planning for clinical precision medicine. In this regard, we have teamed up with many groups, experts, foreign scholars and some companies to conduct multi-directional and multi-disciplinary discussions on the implementation of clinical precision medical treatment. This is a major project that President Fan Jia has been considering since he became the president of Zhongshan Hospital and a major project to be done. Fan Jia is a well-known expert in liver cancer surgery in China and a member of the Chinese Medical Association oncology professional committee. After he became the dean, he once asked us how to make clinical treatment go to the molecular level. We didn't understand the precision medicine at the time, but we know that this is a direction and the future, which can benefit all the people and patients. Therefore, we have done a lot of research in theory. Under the direct support and leadership of the Director of the Department of Science and Education of the Shanghai Municipal Health and Planning Commission, we also established the Shanghai Institute of Clinical Informatics, which gathered Shanghai clinical science. Expert in medical informatics and bioinformatics. Here we discuss how to establish a measurement method for clinical precision medicine, how to analyze the results of our measurements, and how to interpret these results. More important is how you can use these results to treat patients. In this process, we realize that it is true that there is a long way to go. In this regard, Zhongshan Hospital has done a lot of work and established the Clinical Medical Research Institute. Vice President Zhou Wei is the Dean of the Clinical Medical Research Institute, and has 19 research institutes, 6 provincial and municipal key laboratories and centers. More than 20 research platforms are integrated into one, focusing on superior resources and overcoming scientific difficulties. In our imagination, the realization of clinical precision medicine is a re-emergence of wisdom, but also a re-aggregation of resources. If you have time to take a look at the "New England Magazine" published on May 19th by the NIH President Professor Collin, one of the two directions of precision medicine in 2016 is to integrate superior resources, give play to the strengths, and solve the priority problem. Nowadays, clinical precision medicine has developed rapidly. The state attaches great importance to this. In the major plan of the "13th Five-Year Plan", the application for precision medicine has just ended, the first trial has ended, and many experts have entered the first trial. With the support of President Zhang Yanling, the Chinese Medical Doctor Association was jointly advocated by Academician Wu Mengchao and Academician Xia Jinglin, Academician Wang Hongyang, and I have just established the Clinical Accuracy Medical Professional Committee of the Chinese Medical Doctor Association. Wang Hongyang, a well-known liver cancer expert, director of the National Liver Cancer Center, and deputy director of the Eastern Hepatobiliary Surgery Hospital of the Second Military Medical University, served as the chairman. The establishment of the Clinical Precision Medical Professional Committee marks that China has an organization in the medical community. This shows that China's clinical precision medicine has to be standardized, standardized and rationalized. As Academician Wang Hongyang said at the opening ceremony, China's clinical precision medicine has unlimited prospects, and patients are expecting it to come, but how can we truly standardize and standardize it, how can we reassure patients, this is what we face. Great task and challenge. When it comes to the concept of precision medicine and precision medicine, many doctors and patients will ask us: We have been treating Chinese patients for thousands of years, including Chinese medicine, which has always been accurate and has always been correct. It is true that all doctors are treating patients correctly and trying to be precise, but the precise medical treatment that is said today may be quite different from this concept. The precise medical treatment we talked about today is really at the genetic level, in the molecular At the level of understanding and understanding the origin of the disease, the occurrence and development of the disease, and the ability to find a truly accurate targeted molecular treatment, this treatment avoids the general treatment. Generalized treatment may be effective, but it may also kill many innocent normal cells. Therefore, precision medicine will bring benefits to patients, and in the process of treatment, the effect will be better, the better will be better, and the medical expenses will be less. Of course, this requires us to work hard and prove, but I believe or I have confidence that this day will come. The five elements of clinical precision medicine Dear friends, I am very honored to have this opportunity to share our own understanding of precision medicine. This understanding may not be complete, it is not very accurate, but we are willing to share it, whether you are a doctor, an expert or a patient. I hope that you can share your understanding with us. I believe that the advancement of medicine is done by our interaction. We really understand that there are five major factors in clinical precision medicine. The five elements of clinical precision medicine are: First, we must have clinical information, patient information, clinical treatment information, and clinical examination information. We call it clinical informatics. Second, when doing precision medicine, especially clinical precision medicine, it is necessary to have precise methodology, accurate measurement, and precise equipment. This is also a very important one. Especially now is the society of goods. When precision medicine appears, there will be many new machines, all kinds of equipment and methods. As everyone has been confused, how to standardize and unify the methods, we can explain the measured results in a standard and accurate way. Third, with these methods, how can we detect and monitor the treatment of precision medicine. Regardless of the treatment given to the patient, there must always be the same indicator used to monitor whether it is good or bad. This is a biomarker. In precision medicine, biomarkers with biological function specificity, biomarkers specific to diseases, and biomarkers with therapeutic specificity are required. In summary, this marker is biologically capable and clinically detectable. This biomarker must be clinically applicable. Many of our experts have worked hard and hard to find many good target molecules, but this is not the biomarker we need because it is not clinically detectable. It can be done in research, but in clinical practice. There are no indicators that can be measured, and we believe that this biomarker needs further improvement and development. Dehydrated Pumpkin Slices
The product requires that the dehydrated pumpkin slices should be light yellow or orange, flaky or filamentous..
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The main processing process of dehydrated pumpkin slices includes raw material cleaning, finishing and cutting, blanching, dehydration and packaging.
Pumpkins for dehydration should be selected from ripe pumpkins with good flavor, smooth skin and orange-red flesh.
Washing Dry the pumpkin in clean water to remove dirt such as mud.
Sorting and cutting Remove the stem of the washed pumpkin, then cut it into two halves with a knife, and peel off the outer skin and the inner pulp and seeds. Cut it into 3-4mm or 6-7mm thin slices (you can also use a grater to smash into filaments).
The blanched and cut melon slices are treated with steam or boiling water for 1-3 minutes, then quickly cooled with cold water, and the water droplets are drained.
Dehydration Put the blanched pumpkin slices into a baking sieve for dehydration. The drying temperature is first controlled at 45-60 °C, and then gradually increased, but cannot exceed 70 °C. Dry until the moisture content of the dry product is below 6%.
