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The first author of this article, EMBL's SimoneLi, said: "Ultimately, our goal is to transform fecal transplants into something more manageable, such as pills. Our work shows that this is likely to be a personalized bacterial cocktail. Rather than a one-size-fits-all solution."
The earliest use of fecal suspension for food poisoning and severe diarrhea, dating back to China in the 4th century, Ge Hong in the Eastern Jin Dynasty (AD 300-400), in his book "Elbow Reserve Emergency", recorded the use of feces at that time Qing treatment of food poisoning and severe diarrhea, "twisting manure, drink a total of one or two liters, said Huanglong soup, Chen Jiujia good", also recorded the use of animal waste to treat diseases, such as "驴矢, 绞æ±5 Liuhe, and hot clothes, set up." In the 16th century, Li Shizhen of the Ming Dynasty in China recorded oral manure water for the treatment of severe diarrhea, fever, vomiting and constipation in the "Compendium of Materia Medica". In 2010, The New York Times reported an article in which a gastroenterologist in the United States successfully cured a patient with a severe infection with Clostridium difficile using a method of fecal transplantation. After that, American academic circles became more interested in fecal transplantation. strong. In recent years, fecal transplantation has gradually become the "new darling" of the mainstream medical profession.
Fecal transplants, also known as fecal microbiota transplants, involve collecting microbes from the donor's feces and delivering them to the patient's intestines. It is hoped that this will help some patients with certain diseases recover, as the normal intestinal microflora balance in these patients becomes disordered. This approach has been very successful in the treatment of recurrent C. diffic infections, which can cause life-threatening diarrhea and is becoming a serious problem in hospitals and medical institutions. In 2013, a Dutch scientist in a study published in the New England Journal of Medicine mixed feces from donors with saline and injected them into the patient's gut system, like dropping a commando to the enemy. Territory. The results show that healthy and diverse intestinal bacteria play a role in a few days, eliminating the intractable C. difficile that antibiotics cannot kill.
Studies have shown that for other diseases, such as ulcerative colitis, stool transplantation is more effective. This study, led by EMBL's PeerBork and Shinichi Sunagawa, can help raise these possibilities. Scientists say that the trick is to look beyond the strains in a person's intestines to find other strains of each species.
For example, most people have E. coli in their gut, but different people carry different strains of this bacterium - some of which may cause health problems. By distinguishing between different strains, EMBL scientists are able to track "when a patient's gut microbes are their own or from a donor after treatment."
They found that after the fecal transplant, if the strain is already in the patient's intestine, the new strain from the donor, this strain, is more likely to colonize the patient's intestine. This means that if the doctor is able to match the donor to the patient, the chances of successful treatment will be greatly increased. Focusing on strains, rather than strains, may also make treatment of certain diseases (which are currently not working in patients with this disease) more effective.
According to WillemdeVos, a microbiologist at Wageningen University and the University of Helsinki, “For example, in this way, we can explore whether an antibiotic-resistant strain can be replaced by a non-resistant strain. So this Can help design a fecal transplant that works in other conditions than c.diff."
The study was based on a clinical trial that explored the use of fecal transplantation as a treatment for metabolic syndrome, which was performed by MaxNieuwdorp of the Amsterdam Academic Medical Center. Although the data collected was only from 10 people, the work has provided strong indications that donor-patient compatibility is more important than imagined: transplant from one donor, among three patients , will produce very different effects.
Original title: Science: Feces transplanted into medical "new darling", "fertilizer tablets" or will come out
Feces transplanted into medical new pet dung pills or will come out
[China Pharmaceutical Network Technology News] The biomedical world is a place to create miracles, there will always be some incredible discovery research that makes you speechless. A research team from the European Molecular Biology Laboratory (EMBL), with researchers from the Wageningen University and Academic Medical Center in the Netherlands and the University of Helsinki in Finland, found that compatibility between donors and patients may be in fecal transplantation. Played a bigger role than previously thought. The study, published in the April 29 issue of Science, may help make fecal transplantation an effective treatment option for more diseases.