Fudan University discovers new pathways for diabetes and cancer

Fudan University discovers new pathways for diabetes and cancer

August 15, 2018 Source: China Education Daily Author: Lee Dong Patio Major

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Clinical studies have found that the proportion of cancer patients with diabetes is significantly higher than non-diabetics, is there a link between diabetes and cancer? The research team of Fudan University recently discovered a new pathway between diabetes and cancer, providing new ideas for cancer prevention and treatment.

"Nature" recently published online research results of the team of Professor Shi Yang and Shi Yujiang from the Biomedical Research Institute of Fudan University, entitled "Glucose through AMPK-mediated phosphorylation of TET2 protein reveals a new pathway for the intrinsic association between diabetes and cancer" .

The research team found that there is a new pathway between diabetes and cancer. The level of hyperglycemia in diabetic patients is better than that of a chain. Under the interlocking chain reaction, the high sugar environment will eventually destroy the formation of 5-hmC apparent tumor suppressor modification, and the apparent tumor suppression modification will be less, and the risk of disease will naturally increase. Studies have shown that some diabetes treatments can effectively reduce the risk of some cancer outbreaks.

The research team believes that less sugar intake, keep blood sugar levels in the body at a low level, reduce the frequency of inhibition of AMPK protein kinase, increase the stability of TET2 protein, increase the level of 5-hmC, and have a positive effect on the prevention and treatment of some tumors. This research will provide direction for drug development in clinical research and cancer prevention.

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