New research finds new effects of intestinal flora

New research finds new effects of intestinal flora

September 13, 2016 Source: Bio Valley

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In a study led by researchers at the University of Cincinnati in the United States, they revealed how intestinal bacteria affect intestinal mast cell activation and fat absorption. The study entitled "Antibiotics Srppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats" was published online in the international academic journal Gastroenterology.

"Changes in fat absorption are very important for the development of obesity," said Dr. Patrick Tso, author of the article. According to the NIH Research Institute for Diabetes and Kidney Diseases, overweight and obesity are risk factors for type 2 diabetes, heart disease, high blood pressure and other health problems. In this study, Tso and his team divided the animal models into two groups, one of which received antibiotic treatment to remove bacteria and the other group as a control group, followed by lipid treatment to compare intestinal fat absorption in the two groups. And mast cell activation.

"Our results indicate that enteric bacteria are involved in mast cell activation mediated by fat digestion and promote fat-induced intestinal permeability," Tso said. He added that the study found that the intestinal flora promotes lipid absorption. A new role.

Mast cells are closely related to the body's immune system. They come from the bone marrow into all tissues of the body, and each mast cell contains secretory granules in which powerful bioactive molecules are stored. When mast cells are activated, these factors can be secreted to cause an allergic and inflammatory response.

Tso also said that mast cells also play a key role in the defense of the gastrointestinal tract against foreign organisms. Although the absorption of fat is indeed associated with the activation of intestinal mucosal mast cells, the specific role of intestinal bacteria is still unclear.

"This effect is specific to the absorption of fat, because the absorption of carbohydrates and proteins does not activate intestinal mucosal mast cells," Tso said.

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