Glial cells are the key to successful brain treatment

Release date: 2018-01-10

The use of implanted devices can release electrical signal stimuli to the nervous system, thereby regulating the abnormal activity of the brain. Currently, we agree that neurons are the only cell type in the brain that needs to be stimulated, according to a recent publication in Nature Biomedical Engineering. An article in the journal is equally important for stimulating some supporting glial cells around neurons.

"Glial cells are the most abundant type of cells in the central nervous system," said Professor Kozai, author of the study. "The most important function of glial cells is scabbing to protect the damage of central nervous cells and the spread of degeneration. However, Their effects on brain function are still unknown."

The results of this study indicate that glial cells are more abundant than previously thought. "In addition to providing growth factors, providing insulation protection, protecting neurons from damage, and recycling waste, glial cells are also able to ensure optimal brain activity," the authors said.

Glial cell electrical signals are very slow and weak and therefore more difficult to detect than neurons. Using advanced technology, authors and others can detect weak interactions of glial cells, and these findings will help to treat neurodegenerative diseases with implanted devices.

The authors say that glial dysfunction is considered to be the cause of a variety of neurological diseases and developmental disorders. Therefore, we have reason to believe that targeting glial cells themselves or in combination with neurons can enhance the therapeutic effect of the disease.

"By combining in vivo multiphoton microscopy and electrophysiological techniques, we are able to observe cell movement and changes in real time, and help explain how glial cells awaken the activity of neural networks. Based on these results, we are expected to improve. The success rate of implanted devices to treat diseases."

Source: Bio Valley

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