Pharmacological effects 1, the role of anti-pathogenic microorganisms Cnidium in the test tube flocculent bacteria, gypsum-like spores, wool-like spores were inhibited. Newcastle virus cultured on chicken embryos can extend chicken embryo life for 6 hours. Cnidium extract (1:2) has a strong killing effect on vaginal trichomoniasis in vitro. However, there are also reports that with liver extract as a medium, 10% and 20% of Cnidium decoction has no killing effect or weak effect on vaginal trichomoniasis. 2, sex hormone-like effect of continuous subcutaneous injection of Cnidium elegans ethanol extract for 32 days, can extend the estrus period, shorten the estrus interval, and can make ovariectomized mice estrus, but also to increase the weight of the ovary and uterus. The method of increasing the weight of the prostate, seminal vesicle, and levator ani muscle (mouse) proved that the Cnidium monnieri extract has an androgen-like effect. Does not corrode vaginal mucosa in rabbits. 3. Killing effect on spermatozoa Cnidium monnieri extract powder was formulated into 20%, 25%, 30%, 35%, and 40% suspensions with physiological saline for 48 hours at room temperature, 200 rpm. 10 minutes, the supernatant was filtered and stored at 4°C. Observing the spermicidal effect with the drug, it can be seen that the spermicidal effect increases with the increase of the concentration of the drug solution. The minimum effective concentration of human sperm in 20 seconds is 30%. Each milliliter of semen is mixed with different doses of Cnidium monnieri extract powder. The minimum effective dose for inhibiting sperm activity is 250-300 mg. Experiments show that Cnidium may become a vaginal contraceptive. 4, anti-allergic effects of animal experiments show: Cnidium acetone extract has a strong antihistamine effect. Can significantly antagonize the contraction of the intestinal muscle caused by histamine, chronic reaction substances, 2% egg white. Cnidium is administered to mice and has a strong inhibitory effect on passive cutaneous anaphylaxis in mice. The intraperitoneal injection of osthole can inhibit the degranulation of rat peritoneal mast cells induced by trichosanthin. 5. Anti-arrhythmic effects The aqueous extract of Cnidium monnieri has preventive effects on chloroform-induced ventricular fibrillation in mice, calcium chloride-induced ventricular fibrillation in rats, and arrhythmia induced by aconitine in rats. There is a clear therapeutic effect. This indicates that Cnidium monnieri water extract has antiarrhythmic effect. It can effectively counteract the ectopic rhythm of aconitine in promoting sodium channel opening and accelerating Na+ influx. It is suggested that the aqueous extract of Cnidium monnieri has a significant inhibitory effect on Na+ and Ca++ influx of myocardial cell membrane, thus exerting an antiarrhythmic effect. 6. The study on the effects of the respiratory system showed that: Cnidium has a strong bronchiectasis, osthole can increase the lung perfusion of guinea pigs, its effect is stronger than aminophylline. Cnidium total coumarin intragastric administration of guinea pigs can increase the duration of asthma attack in guinea pigs caused by histamine and acetylcholine chloride. In vitro experiments demonstrated that total coumarin from Cnidium monnieri has a strong antagonistic effect on histamine-induced tracheal contraction in isolated guinea pigs. The above effects can be blocked by propranolol without affecting the heart rate and blood pressure of the anesthetized animals, suggesting that the total coumarin of Cnidium monnieri may be selectively excited by β2 receptors on bronchial smooth muscle, resulting in antispasmodic and asthmatic effects. Cnidium total coumarin gavage mice, can significantly increase the amount of phenol red discharge, suggesting that the product has a strong scorpion effect. 7, local anesthetic effect Cnidium decoction alcohol decoction (100%) completely block the action potential of the sciatic nerve in vitro, its intensity is the same as 10% procaine, can resume normal conduction function after drug withdrawal The guinea pigs have an infiltrating anesthetic effect, this effect can be enhanced by epinephrine hydrochloride, but the local anesthetic effect is shorter than 10% procaine; rabbit spinal anesthesia effect, but there is no surface anesthesia in rabbit corneas . Examination Nitrile Gloves,Nitrile Gloves,Powder Free Hand Gloves,Disposable Examination Nitrile Gloves Puyang Linshi Medical Supplies Co., Ltd. , https://www.linshihealths.com