Release date: 2016-05-16 Although not everyone wants to live forever, maintaining a young and healthy state must be the way people care. A few days ago, researchers at the University of Washington succeeded in implementing clinical trials to delay aging in dogs, which means that prolonging life may no longer be an unreachable dream. The drug used by the researchers, called rapamycin, was discovered in 1964 by a group of Canadian scientists and found in the secretions of bacteria in the soil of Easter Island. Rapamycin, the name of the island of Easter Island - Repa Island. Successfully tested on dogs for the first time As a novel macrolide immunosuppressant, rapamycin is an inhibitor of mammalian rapamycin target complex 1 (mTORC1), which blocks T lymphocytes and other cells from G1 to S The process of the period, thereby exerting an immunosuppressive effect. From the clinical application point of view, rapamycin has a good anti-rejection effect and has been successfully applied to mice. Kaeberlein and Daniel Promislow of the University of Washington began experimenting with the drug on dogs in March 2015. The results were shocking: "The efficacy of rapamycin in delaying aging is shocking. The only question is whether it has a negative effect on the human body." Kaeberlein chose a pet dog. One reason is that the living conditions and habits of the dog are more close to the life of the mouse. On the other hand, the life span of the dog is relatively short, mostly in 10 to 13 years. If the dog can be delayed Dog aging, then it can accompany people for a longer time. "If we can delay the life of a dog, it will also improve our quality of life to a certain extent. At the same time, it also provides a foresight for the continuation of human life." In this experiment, a total of 40 volunteer pet dogs were enrolled. Except for 16 pet dogs with heart disease, the 24 dogs participating in the experiment took three rapamycin tablets provided by the experiment every day, and the ECG was performed after 10 weeks. Compared. The results showed that the dog's heart function was improved or maintained in a normal state. Next, the experimenter plans to conduct a year-long experiment to see if rapamycin can become an anti-aging star in the next decade. Rapamycin fish and bear's paw can not have both Rapamycin is not actually considered to have anti-aging effects for the first time. As early as 2009, three well-known research anti-aging units conducted rapamycin mouse experiments under the auspices of the American Institutes of Health. The study found that male mice using rapamycin can prolong 9% of life. The life span of female mice was extended by 14%. At the same time, the researchers also found that rapamycin can have a therapeutic effect on aging-induced cancer or Alzheimer's disease. Three years later, these related institutions found in subsequent studies that rapamycin can slow the rate of tendon sclerosis and liver function degradation, which are just two signs of aging. In 2014, Novartis announced in Science and Translational Medicine that rapamycin significantly improved the immune system function of the elderly. "If aging is a major cause of fatal disease, the way to prolong life is to delay aging," said Neil Bartzley, director of the Institute of Aging at the Albert Einstein College of Medicine in New York City. The basis of aging. "With the exception of rapamycin, there are no drugs that can really extend the maximum lifespan of mammals," said Professor Liu Xianglin, a postdoctoral fellow at New York University. "It extends the maximum lifespan of experimental mice (10% in the population). The average life expectancy, not the average life limit, is the sign of delaying aging." In 2013, American scientists pointed out in Science that in addition to inhibiting mTORC1 activity (delaying aging), rapamycin also disrupts the function of mTORC2, thereby activating insulin-mediated hepatic gluconeogenesis. In other words, rapamycin acts on both mTORC1 and mTORC2, delaying aging on the one hand and causing symptoms of diabetes on the other. Therefore, if you want to make rapamycin truly applied to the human body, look for ways to not destroy mTORC2. In addition to this, rapamycin has a reversible dose-dependent, and no significant nephrotoxicity has been found in the therapeutic dose of rapamycin. Although there are no additional side effects found on the clinical level for a while, it is still to be further understood as a drug that can be applied to human body anti-aging. But just thinking about the possibility that we have this today is enough to make people happy. Source: Lei Feng Net
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