Anti-trichomonad effect Cnidium has been used for the treatment of trichomonal vaginitis with external use of Chinese medicine, but the effect of single-snake Cnidium has been unsatisfactory or extremely weak, and its action components have not been reported. The compound Cnidium suppository or lotion works well. Sex hormone-like effects Cnidium ethanol extract, daily subcutaneous injection in mice for 32 consecutive days, can extend the estrus period, shorten the estrus interval, and can make estrus rats appear estrus, ovarian and uterine weight increases, there is a similar sex hormone-like effect to the prostate The method of increasing the weight of the seminal vesicles, the seminal vesicles, and the levator ani (mouse) demonstrated that the extract from the Cnidium monnieri has androgenic hormone-like effects without corrosive effects on the rabbit vaginal mucosa. Antiasthmatic effect 3.1 Cnidium total coumarin has anti-asthmatic effects, can significantly reduce or disappear the wheezing of asthmatic patients' lungs, and can significantly increase the peak expiratory flow rate and improve pulmonary ventilation. Its role is the expansion of bronchial smooth muscle and improve lung ventilation function. This suggests that total coumarin in Cnidium monnieri may have a role as a B-agonist, and its antiasthmatic effect may be through activation of smooth muscle and the regulatory subunit of adenylyl cyclase on the cell membrane (B-receptor). The increase of intracellular cAMP results in the phosphorylation of proteins in the intracellular storage site. The uptake of Ca2+ causes Ca2+ to enter the binding state, thereby reducing the intracellular free Ca2+, decreasing the excitability of the smooth muscle contraction protein system, and achieving muscle relaxation. 3.2 Cnidium total coumarin also has a certain role. 3.3 Cnidium total coumarin has obvious protective effect on experimental asthma caused by inhalation of tinea in guinea pigs. Relaxation of histamine-induced tracheal smooth muscle in vitro can enhance the lung perfusion of guinea pigs. Has a strong bronchiectasis effect. Other effects In recent years, there have been more studies on Cnidium monnieri and more and more pharmacological effects have been discovered. 4.1 Antifungal effects: In vitro tests of osthole, bergapten, and diterpene have a strong activity against the hair fungus of Trichophyton spp. Zanthoxyl phenol has a significant antimycotic effect. 4.2 Antiarrhythmics: The water extract of Cnidium monnieri has a preventive effect on chloroform-induced ventricular fibrillation in mice, calcium chloride-induced ventricular fibrillation in rats, and atrial arrhythmias induced by totounitine in rats. There are also obvious therapeutic effects. 4.3 Local anesthetic effect: The aqueous extract of Cnidium monnieri has block anesthetic effect on isolated sciatic nerve of guinea pigs; it has infiltration and anesthetic effect on guinea pigs and can be enhanced by epinephrine hydrochloride; it has spinal anesthetic effect on rabbits, but There is no surface anesthetic effect on the rabbit cornea, but it can also significantly prolong the sleeping time of pentobarbital sodium. 4.4 Anti-allergic reactions: Osthole can strongly inhibit passive cutaneous anaphylaxis in mice, protect guinea pigs against histamine-like wheezing, isolate isolated ileum from guinea pigs caused by slow-reaction substances, and excise the isolated ileum of guinea pigs. The Schultz-Dzle response shows marked antagonistic and blocking effects and inhibits degranulation of rat peritoneal mast cells. The above effects showed a dose-dependent relationship. 4.5 Antimutagenicity: Aqueous extract of Cnidium monnieri, through the sister chromatid exchange between Ames, ex vivo cells, chromosome aberrations of mouse bone marrow cells in vivo, and micronucleus test of polychromatic erythrocytes, showed that the drug was strong Antimutagenic effect. 4.6 Insecticide: Putting the Cnidium into the sewage can kill the clams. Hospital Nitrile Gloves,Exam Nitrile Gloves,Nitrile Gloves Bulk,Medical Hand Gloves Powder Free Puyang Linshi Medical Supplies Co., Ltd. , https://www.linshimedicals.com